EGS:NP is a sub-comic of El Goonish Shive
If you have not read El Goonish Shive, EGS:NP will likely be confusing at times and full of spoilers. The "NP" stands for NewsPaper, and is in reference to nothing other than the format of the strips.
This is the first EGS:NP story. It focuses on Tedd, a normally male mad scientist who apparently forgot to turn himself back to normal before school after turning himself into a girl.
Beyond this point, the editorials will boldly assume you've either read the main story comics and know who these characters are, or simply don't care ;)